Improving the bioavailability of quercetin with novel nanocarriers
Quercetin is a flavonoid with strong antioxidant activity, found in many fruits and vegetables. The promising pharmaceutical applications of quercetin are hindered by the low bioavailability of this compound. This limitation can be overcome with an appropriate formulation, designed to improve the solubility of quercetin in gastrointestinal fluids and to protect the compound from degradation. This project presents a multidisciplinary approach for the development of micellar formulations of quercetin using carrier materials with surfactant properties, performed in cooperation by the High Pressure Processes Group of the University of Valladolid, the Department of Physiology and Pharmacology of the University of Salamanca, Institute of Experimental Biology and Technology (iBET), and the innovation-based company Bio In-Ren. The micellar formulations in aqueous phase will be prepared applying the supercritical fluid extraction of emulsions process (SFEE) patented by the High Pressure Processes Group. The bioavailability of the prepared formulations will be characterized with in-vitro and in-vivo assays, and finally the possible therapeutic activity of the compound will be evaluated.
Project Title: Mejora de la biodisponibilidad de la quercetina mediante el desarrollo de nanoportadores por extracción supercrítica de emulsiones.
Project Code: VA225U14.
Funding Organization: Junta de Castilla y León.
Period of realization: January 2015 – December 2016.
Principal Investigator: Ángel Martín Martínez – High Pressure Processes Group, University of Valladolid.
From the High Pressure Processes Group, University of Valladolid: Gloria Esther Alonso Sánchez, Soraya Rodríguez Rojo, Alexander Navarrete, Óscar Benito Román, Gyorgy Lévai.
From the Department of Physiology and Pharmacology of the University of Salamanca: Sandra Sancho Martínez, Laura Prieto Garcría.
From iBET (Instituto de Biologia Experimental Tecnológica , Oeiras, Portugal): Ana Matias, Vanessa Gonçalves.