We have studied the encapsulation of quercetin antioxidants in poloxamer surfactants (Pluronic (R)) with the objective of achieving a formulation with an enhanced solubility in aqueous media that can improve the bioavailability of this compound. A Supercritical Antisolvent (SAS) precipitation technique has been employed. (go to journal)
We have achieved a significant reduction of particle size down to the submicrometer range, and a homogeneous dispersion of quercetin in an amorphous polymer matrix. Due to the morphological and structural properties conferred by SAS processing, formulations showed a faster dissolution and a higher final solubility in simulated gastric and intestinal fluids than unprocessed quercetin or a physical mixture of quercetin with Pluronic.
A full report of our results is presented in this publication:
Marta Fraile, Rafaella Buratto, Beatriz Gómez, Ángel Martín, María José Cocero. Enhanced delivery of quercetin by encapsulation in poloxamers by supercritical antisolvent process. Industrial & Engineering Chemistry Research 53,11 (2014) 4318-4327.
This publication is available at the ACS website through the following link: