[Paper] Enhanced delivery of quercetin by encapsulation in poloxamers by supercritical antisolvent process

Quercetin_01We have studied  the encapsulation of quercetin antioxidants in poloxamer surfactants (Pluronic (R)) with the objective of achieving a formulation with an enhanced solubility in aqueous media that can improve the bioavailability of this compound. A Supercritical Antisolvent (SAS) precipitation technique has been employed. (go to journal)

We have achieved a significant reduction of particle size down to the submicrometer range, and a homogeneous dispersion of quercetin in an amorphous polymer matrix. Due to the morphological and structural properties conferred by SAS processing, formulations showed a faster dissolution and a higher final solubility in simulated gastric and intestinal fluids than unprocessed quercetin or a physical mixture of quercetin with Pluronic.

A full report of our results is presented in this publication:

Marta Fraile, Rafaella Buratto, Beatriz Gómez, Ángel Martín, María José Cocero.  Enhanced delivery of quercetin by encapsulation in poloxamers by supercritical antisolvent process. Industrial & Engineering Chemistry Research 53,11 (2014) 4318-4327.

This publication is available at the ACS website through the following link:

http://pubs.acs.org/doi/abs/10.1021/ie5001136

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